منابع مشابه
Sonic hedgehog
Are there related proteins? Lots. In mammals, Sonic is related to two other hedgehogs: Indian and Desert. When expressed appropriately, the three proteins can substitute for one another but they do have unique functions: Desert hedgehog is needed for spermatogenesis and Indian hedgehog regulates cartilage differentiation. In the zebrafish, Sonic is related to Tiggywinkle hedgehog — which is tho...
متن کاملSonic Hedgehog in SCLC
signal transduction pathway has been discovered as a central regulator of embryonic development, tissue maintenance and repair [1]. Moreover, several recent evidences have highlighted its key function in tumorigenesis [2]. In some familial cancers, such as basal cell carcinoma and medulloblastoma, Hh pathway activation represents the initial tumorigenic event, whereas in other human malignancie...
متن کاملInhibitors of Hedgehog Acyltransferase Block Sonic Hedgehog Signaling
Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat. In cells, these Hhat inhibitors specifically block Shh palmi...
متن کاملSonic Hedgehog Signaling in Thyroid Cancer
Thyroid cancer is the most common malignancy of the endocrine system. The initiation of thyroid cancer is often triggered by a genetic mutation in the phosphortidylinositol-3 kinase (PI3K) or mitogen-activated protein kinase (MAPK) pathway, such as RAS and BRAF, or by the rearrangement of growth factor receptor tyrosine kinase genes such as RET/PTC. The sonic hedgehog (Shh) pathway is evolution...
متن کاملSignal dynamics in Sonic hedgehog tissue patterning.
During development, secreted signaling factors, called morphogens, instruct cells to adopt specific mature phenotypes. However, the mechanisms that morphogen systems employ to establish a precise concentration gradient for patterning tissue architecture are highly complex and are typically analyzed only at long times after secretion (i.e. steady state). We have developed a theoretical model tha...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1998
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(07)00475-7